AGN 192403 hydrochloride

Base Information

• Chemical Name: AGN 192403 hydrochloride
• CAS No.: 175521-95-6
• Molecular Formula: C10H19N
• Molecular Weight: 189.73
• European Community (EC) Number: 635-754-5
• Mol file: 175521-95-6.mol

Synonyms:3-propan-2-ylbicyclo(2.2.1)heptan-2-amine;hydrochloride;AGN 192403 hydrochloride;BRD4780

Chemical Property of AGN 192403 hydrochloride

Chemical Property:

• Vapor Pressure: 0.284mmHg at 25°C
• Boiling Point: 203°C at 760 mmHg
• Flash Point: 63.9°C
• PSA: 26.02000
• LogP: 3.51810
• Storage Temp.: Store at RT
• Solubility.: H2O: 20 mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 189.1284273
• Heavy Atom Count: 12
• Complexity: 153

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

AGN 192403 hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1C2CCC(C2)C1N.Cl
• Uses: AGN 192403 Hydrochloride is the hydrochloride salt of AGN 192403, which is a known midazoline drugs with a postulated high affinity to imidazoline I1 receptor.

Technology Process of AGN 192403 hydrochloride

There total 2 articles about AGN 192403 hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-3-isopropyl-2-nitrobicyclo[2.2.1]hept-5-ene → rac-3-isopropylbicyclo[2.2.1]hept-5-en-2-amine (175521-95-6)

Guidance literature:

With ammonium formate; zinc; In methanol; water; at 20 ℃; for 12h;

DOI:10.1021/acs.joc.0c02520

Reference yield:

→ 3-Isopropyl-2-norbornanamin (25220-12-6,175521-95-6)

Guidance literature:

Nitroverbindung I, katalytische Hydrierung;

Reference yield: 58.0%

(±)-2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane (175521-95-6) + phthalic anhydride (85-44-9) → rac-2-((1R,2R,3R,4S)-3-isopropylbicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione

Guidance literature:

In N,N-dimethyl acetamide; at 180 ℃; for 3h;