N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide

Base Information

Chemical Name:N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide
CAS No.:1552270-14-0
Molecular Formula:C₂₅H₂₅NO₄S
Molecular Weight:435.544
Hs Code.:

Synonyms:N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide

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Chemical Property of N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide

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Technology Process of N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide

There total 8 articles about N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 180530-10-3
N-(3-iodophenyl)methanesulfonamide

: 1552270-13-9
2-[(1E)-1-(10-methoxy-6H-benzo[c][2]benzoxepin-11-ylidene)propyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1552270-14-0
N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 3,5-dimethoxyphenol; potassium hydroxide; In 1,4-dioxane; water; at 80 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm401616g

Reference yield:

: 533-58-4
2-Iodophenol

: 1552270-14-0
N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / N,N-dimethyl-formamide

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 50 °C / Inert atmosphere

3: oxalic acid / methanol; water / 72 h / 55 °C

4: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / benzene / 18 h / 0 - 50 °C

5: tetrakis(triphenylphosphine)platinum / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

6: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

7: 3,5-dimethoxyphenol; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 3,5-dimethoxyphenol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrakis(triphenylphosphine)platinum; tributylphosphine; oxalic acid; sodium hydride; triethylamine; potassium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; benzene; 2: |Sonogashira Cross-Coupling / 4: |Mitsunobu Displacement;
DOI:10.1021/jm401616g

Reference yield:

: 1552270-10-6
1-but-1-ynyl-2-(methoxymethoxy)benzene

: 1552270-14-0
N-[3-[(1Z)-1-(10-methoxy-6H-benzo[c][1]benzoxepin-11-ylidene)propyl]phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: oxalic acid / methanol; water / 72 h / 55 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / benzene / 18 h / 0 - 50 °C

3: tetrakis(triphenylphosphine)platinum / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

4: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

5: 3,5-dimethoxyphenol; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 3,5-dimethoxyphenol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrakis(triphenylphosphine)platinum; tributylphosphine; oxalic acid; potassium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; benzene; 2: |Mitsunobu Displacement;
DOI:10.1021/jm401616g