6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one

Base Information

Chemical Name:6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one
CAS No.:875269-83-3
Molecular Formula:C₂₃H₂₆BrN₃O₂
Molecular Weight:456.382
Hs Code.:

Synonyms:6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one

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Chemical Property of 6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one

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Technology Process of 6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one

There total 1 articles about 6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 693820-77-8
6-bromo-2-(2-methoxyphenyl)-4H-3,1-benzoxazin-4-one

: 1-[1-(cyclopropylmethyl)piperidin-3-yl]methanamine dihydrochloride

: 875269-83-3
6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one

Guidance literature:: 6-bromo-2-(2-methoxyphenyl)-4H-3,1-benzoxazin-4-one; 1-[1-(cyclopropylmethyl)piperidin-3-yl]methanamine dihydrochloride; With triethylamine; In toluene; for 15h; Heating / reflux;

With sodium hydroxide; In ethylene glycol; toluene; at 180 ℃; for 3h;

Reference yield: 47.0%

: 875269-83-3
6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one

: 63503-60-6
3-chlorophenylboronic acid

: 76-05-1
trifluoroacetic acid

: 6-(3-chlorophenyl)-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one trifluoroacetate

Guidance literature:: 6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one; 3-chlorophenylboronic acid; With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; toluene; at 100 ℃; for 60h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield: 35.0%

: 98-10-2
benzenesulfonamide

: 875269-83-3
6-bromo-3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)quinazolin-4(3H)-one

: N-[3-[(1-ethylpiperidin-3-yl)methyl]-2-(2-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl]benzenesulfonamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 16h;