2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

Base Information

Chemical Name:2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine
CAS No.:119898-76-9
Molecular Formula:C₃₁H₃₁Cl₂N₅O₄
Molecular Weight:608.524
Hs Code.:

Synonyms:2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

Suppliers and Price of 2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

Chemical Property:

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Technology Process of 2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

There total 6 articles about 2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 119898-71-4
5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-mesyl-2',3'-secoadenosine

: 119898-76-9
2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 3h;
DOI:10.1016/S0040-4020(01)89829-X

Reference yield:

: 57018-82-3,81352-25-2
5'-O-dimethoxytrityladenosine

: 119898-76-9
2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / sodium periodate / acetone; H₂O / 24 h / Ambient temperature; dark

2: 79 percent / sodium borohydride / ethanol; H₂O / Ambient temperature; pH = 7

3: 90 percent / pyridine / 0 °C

4: 97 percent / LiCl / dimethylformamide / 3 h / 100 °C

With sodium tetrahydroborate; sodium periodate; lithium chloride; In pyridine; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)89829-X

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 119898-76-9
2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / pyridine / 96 h / Ambient temperature

2: 91 percent / sodium periodate / acetone; H₂O / 24 h / Ambient temperature; dark

3: 79 percent / sodium borohydride / ethanol; H₂O / Ambient temperature; pH = 7

4: 90 percent / pyridine / 0 °C

5: 97 percent / LiCl / dimethylformamide / 3 h / 100 °C

With sodium tetrahydroborate; sodium periodate; lithium chloride; In pyridine; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)89829-X