{2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester

Base Information

• Chemical Name: {2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester
• CAS No.: 239103-18-5
• Molecular Formula: C₃₂H₄₂N₂O₃Si
• Molecular Weight: 530.783
• Mol file: 239103-18-5.mol

Synonyms:{2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester

Chemical Property of {2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester

There total 6 articles about {2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{2-[3-azido-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester (239103-17-4) → {2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester (239103-18-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jo990469g

Reference yield:

1-Bromo-2-iodobenzene (583-55-1) → {2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester (239103-18-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / BINAP, NaOBu-t / Pd(DBA)3 / toluene / 80 °C

2: Bu₃SnF / Pd(Tol₃P)2Cl₂ / benzene / Heating

3: H₂ / Pd/C / ethyl acetate

With hydrogen; tributyltin fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; bis(tris(4-methyl)phenylphosphine)palladium dichloride; In ethyl acetate; toluene; benzene;

DOI:10.1021/jo990469g

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → {2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester (239103-18-5)

Guidance literature:

Multi-step reaction with 5 steps

1: imidazole / dimethylformamide

2: TFA / CH₂Cl₂

3: 66 percent / BINAP, NaOBu-t / Pd(DBA)3 / toluene / 80 °C

4: Bu₃SnF / Pd(Tol₃P)2Cl₂ / benzene / Heating

5: H₂ / Pd/C / ethyl acetate

With 1H-imidazole; hydrogen; tributyltin fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; bis(tris(4-methyl)phenylphosphine)palladium dichloride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1021/jo990469g

upstream raw materials:

{2-[3-azido-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester

1-Bromo-2-iodobenzene

tert-butylchlorodiphenylsilane

(3S,4S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidine

Downstream raw materials:

{2-[2-oxo-3-(toluene-4-sulfonyl)-hexahydro-pyrrolo[3,4-d]oxazol-5-yl]-phenyl}-acetic acid tert-butyl ester

Diazo-{2-[(3aS,6aR)-2-oxo-3-(toluene-4-sulfonyl)-hexahydro-pyrrolo[3,4-d]oxazol-5-yl]-phenyl}-acetic acid methyl ester

{2-[(3R,4S)-3-Hydroxy-4-(toluene-4-sulfonylamino)-pyrrolidin-1-yl]-phenyl}-acetic acid tert-butyl ester

C₂₁H₁₈N₂O₆S