Technology Process of 3-[4-(2-aminopyridin-6-ylethyl)benzoylamino]-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester
There total 9 articles about 3-[4-(2-aminopyridin-6-ylethyl)benzoylamino]-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
N,N-dimethyl-formamide;
for 16h;
DOI:10.1021/jm000133v
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent / Et3N; (Ph3P)2PdCl2; CuI / acetonitrile / 18 h / 100 °C
2: 90 percent / K2CO3 / ethanol / 16 h
3: 55 percent / Et3N; (Ph3P)2PdCl2; CuI / acetonitrile / 3 h / 100 °C
4: H2 / 10 percent Pd/C / ethanol / 20 h / 760 Torr
5: 6 N HCl / 20 h / 60 °C
6: 83 percent / EDC; HOBT; N-methylmorpholine / dimethylformamide / 16 h
With
4-methyl-morpholine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl-formamide; acetonitrile;
1: Substitution / 2: desilylation / 3: Substitution / 4: Catalytic hydrogenation / 5: Hydrolysis / 6: Condensation;
DOI:10.1021/jm000133v
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 55 percent / Et3N; (Ph3P)2PdCl2; CuI / acetonitrile / 3 h / 100 °C
2: H2 / 10 percent Pd/C / ethanol / 20 h / 760 Torr
3: 6 N HCl / 20 h / 60 °C
4: 83 percent / EDC; HOBT; N-methylmorpholine / dimethylformamide / 16 h
With
4-methyl-morpholine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl-formamide; acetonitrile;
1: Substitution / 2: Catalytic hydrogenation / 3: Hydrolysis / 4: Condensation;
DOI:10.1021/jm000133v
