2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide

Base Information

• Chemical Name: 2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide
• CAS No.: 1574075-61-8
• Molecular Formula: C₂₅H₂₂N₆O₆S₂
• Molecular Weight: 566.618

Synonyms:2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide

Chemical Property of 2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide

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Technology Process of 2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide

There total 3 articles about 2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + 2-((5-((styrylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)-methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide (1574075-36-7) → 2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide (1574075-61-8)

Guidance literature:

With sodium hydride; In diethyl ether; dimethyl sulfoxide; at 20 ℃;

DOI:10.1002/ardp.201300290

Reference yield:

(Z)-β-styrylsulfonylacetic acid (92207-24-4,102154-41-6) → 2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide (1574075-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / Reflux

2: sodium hydride / diethyl ether; dimethyl sulfoxide / 20 °C

With sodium hydride; trichlorophosphate; In diethyl ether; dimethyl sulfoxide;

DOI:10.1002/ardp.201300290

Reference yield:

2-((4-phenyl-1H-imidazol-2-ylcarbamoyl)methylsulfonyl)acetohydrazide → 2-((5-((4-phenyl-1H-pyrrol-3-ylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide (1574075-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / Reflux

2: sodium hydride / diethyl ether; dimethyl sulfoxide / 20 °C

With sodium hydride; trichlorophosphate; In diethyl ether; dimethyl sulfoxide;

DOI:10.1002/ardp.201300290

upstream raw materials:

(Z)-β-styrylsulfonylacetic acid

[(p-methylphenyl)sulfonylmethyl]isonitrile

2-((5-((styrylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)-methylsulfonyl)-N-(4-phenyl-1H-imidazol-2-yl)acetamide

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