3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol

Base Information

Chemical Name:3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol
CAS No.:156564-14-6
Molecular Formula:C₂₆H₃₂O₂Si
Molecular Weight:404.624
Hs Code.:

Synonyms:3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol

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Chemical Property of 3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol

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Technology Process of 3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol

There total 3 articles about 3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 107-19-7
propargyl alcohol

: 156564-13-5
Trifluoro-methanesulfonic acid 5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl ester

: 156564-14-6
3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol

Guidance literature:: With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo00083a007

Reference yield:

: 126822-71-7
1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane

: 156564-14-6
3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Cs₂CO₃, 2.) p-NH₂PhSH, Cs₂CO₃ / 1.) DMF, 70 deg C, 2.) DMF, 85 deg C

2: 99 percent / LDA / tetrahydrofuran / 0 °C

3: 91 percent / CuI, Et₂NH / PdCl₂(PPh₃)2 / dimethylformamide / Ambient temperature

With copper(l) iodide; caesium carbonate; diethylamine; lithium diisopropyl amide; 4-aminotiophenol; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00083a007

Reference yield:

: 156564-12-4
2-(2-(tert-butyldiphenylsilyloxy)ethyl)-cyclopentanone

: 156564-14-6
3-{5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-cyclopent-1-enyl}-prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / LDA / tetrahydrofuran / 0 °C

2: 91 percent / CuI, Et₂NH / PdCl₂(PPh₃)2 / dimethylformamide / Ambient temperature

With copper(l) iodide; diethylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00083a007