[[2-[2-[2-[2-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]methoxy]carbamic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: [[2-[2-[2-[2-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]methoxy]carbamic acid 1,1-dimethylethyl ester
• CAS No.: 299931-19-4
• Molecular Formula: C₃₀H₄₃F₃N₆O₈S
• Molecular Weight: 704.768
• Mol file: 299931-19-4.mol

Synonyms:2-[2-[2-(2-biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyloxycarbamic acid tert-butyl ester

Chemical Property of [[2-[2-[2-[2-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]methoxy]carbamic acid 1,1-dimethylethyl ester

Chemical Property:

• Density: 1.44±0.1 g/cm3 (20 oC 760 Torr)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [[2-[2-[2-[2-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]methoxy]carbamic acid 1,1-dimethylethyl ester

There total 2 articles about [[2-[2-[2-[2-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]methoxy]carbamic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-[2-[2-(biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyloxyamine (308085-26-9) → 2-[2-[2-(2-biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyloxycarbamic acid tert-butyl ester (299931-19-4)

Guidance literature:

With triethylamine; In chloroform; acetonitrile; at 20 ℃; for 14h;

Reference yield:

2-[2-[2-(2-biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide (299931-17-2) → 2-[2-[2-(2-biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyloxycarbamic acid tert-butyl ester (299931-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂NH₂ / methanol / 0.5 h / 20 °C

2: 64 mg / Et₃N / CHCl₃; acetonitrile / 20 °C

With triethylamine; hydrazine; In methanol; chloroform; acetonitrile; 1: amide cleavage / 2: Condensation;

DOI:10.1021/jo000414a

Reference yield:

2-[2-[2-(2-biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyloxycarbamic acid tert-butyl ester (299931-19-4) → 2-[2-[2-(biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyloxyamine (308085-26-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tet.2005.06.022

upstream raw materials:

di-tert-butyl dicarbonate

2-[2-[2-(biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyloxyamine

2-[2-[2-(2-biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzyloxyphthalimide

Downstream raw materials:

2-[2-[2-(biotinylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyloxyamine