3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Base Information

Chemical Name:3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester
CAS No.:116556-60-6
Molecular Formula:C₄₃H₄₉N₃O₈S
Molecular Weight:767.943
Hs Code.:

3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Synonyms:3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

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Chemical Property of 3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

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Technology Process of 3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

There total 13 articles about 3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 116556-58-2
3-benzyloxycarbonyl-5-(3-hydroxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

: 98-59-9
p-toluenesulfonyl chloride

: 116556-60-6
3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Guidance literature:: With pyridine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86862-9

Reference yield:

: 116527-78-7,116556-53-7
2-(3-benzyloxypropyl)-2,3,5,6,11,11b-hexahydro-1H-indolizino<8,7-b>indol-3-on

: 116556-60-6
3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / Lithium aluminium hydride / tetrahydrofuran / 1 h / Heating

2: 1.) water; / 1.) aceton; 2.) 50 deg C, 1 h

3: 68 percent / HCl / CH₂Cl₂ / 2 h / Ambient temperature

4: triethylamine, tert.-butylhypochlorite / CCl₄; CH₂Cl₂ / 0 °C

5: silver tetrafluoroborate / CH₂Cl₂; acetonitrile / 1 h / Heating

6: acetic acid, H₂, Pd/C / propan-2-ol; ethyl acetate / 20 h / 50 °C

7: potassium carbonate / CH₂Cl₂ / 2 h

8: 68 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

With pyridine; hydrogenchloride; palladium on activated charcoal; lithium aluminium tetrahydride; silver tetrafluoroborate; tert-butylhypochlorite; water; hydrogen; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1016/S0040-4020(01)86862-9

Reference yield:

: 116527-79-8,116527-80-1
2-(3-benzyloxypropyl)-2,3,5,6,11,11b-hexahydro-1H-indolizino<8,7-b>indol

: 116556-60-6
3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) water; / 1.) aceton; 2.) 50 deg C, 1 h

2: 68 percent / HCl / CH₂Cl₂ / 2 h / Ambient temperature

3: triethylamine, tert.-butylhypochlorite / CCl₄; CH₂Cl₂ / 0 °C

4: silver tetrafluoroborate / CH₂Cl₂; acetonitrile / 1 h / Heating

5: acetic acid, H₂, Pd/C / propan-2-ol; ethyl acetate / 20 h / 50 °C

6: potassium carbonate / CH₂Cl₂ / 2 h

7: 68 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

With pyridine; hydrogenchloride; palladium on activated charcoal; silver tetrafluoroborate; tert-butylhypochlorite; water; hydrogen; potassium carbonate; acetic acid; triethylamine; In tetrachloromethane; dichloromethane; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1016/S0040-4020(01)86862-9