5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal

Base Information

Chemical Name:5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal
CAS No.:301346-39-4
Molecular Formula:C₂₇H₄₂O₃Si₂
Molecular Weight:470.8
Hs Code.:

5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-pentanal

Synonyms:5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal

Suppliers and Price of 5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal

There total 14 articles about 5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 301346-38-3
(S)-5-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)pentan-1-ol

: 301346-39-4
5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.3762/bjoc.7.158

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 301346-39-4
5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / TfOH / diethyl ether / 1 h

2: 93 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

3: 93 percent / DMAP; Et₃N / CH₂Cl₂

4: 93 percent / imidazole / dimethylformamide

5: 94 percent / DDQ; H₂O / CH₂Cl₂ / 0 °C

6: 85 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide / CH₂Cl₂

With 1H-imidazole; dmap; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; trifluorormethanesulfonic acid; water; 4-methylmorpholine N-oxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Reduction / 3: Substitution / 4: Substitution / 5: Hydrolysis / 6: Oxidation;
DOI:10.1021/jo000327i

Reference yield:

: 6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
D-Glutamic acid

: 301346-39-4
5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-pentanal

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaNO₂; HCl / H₂O

1.2: Me₂S*BH₃

2.1: 81 percent / TfOH / diethyl ether / 1 h

3.1: 93 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

4.1: 93 percent / DMAP; Et₃N / CH₂Cl₂

5.1: 93 percent / imidazole / dimethylformamide

6.1: 94 percent / DDQ; H₂O / CH₂Cl₂ / 0 °C

7.1: 85 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide / CH₂Cl₂

With 1H-imidazole; hydrogenchloride; dmap; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; trifluorormethanesulfonic acid; water; 4-methylmorpholine N-oxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium nitrite; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Diazotization / 1.2: Cyclization / 2.1: Substitution / 3.1: Reduction / 4.1: Substitution / 5.1: Substitution / 6.1: Hydrolysis / 7.1: Oxidation;
DOI:10.1021/jo000327i