(3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate

Base Information

Chemical Name:(3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate
CAS No.:207856-85-7
Molecular Formula:C₁₈H₂₅NO₃
Molecular Weight:303.401
Hs Code.:

Synonyms:(3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate

Suppliers and Price of (3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of (3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of (3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate

There total 7 articles about (3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 207856-85-7
(3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate

Guidance literature:

Reference yield:

: 13220-33-2,99445-21-3
1-methyl-3-pyrrolidinol

: 64471-45-0
(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid

: 616866-21-8
(2R,3'R)-3'-(2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1'-methylpyrrolidine

: 207856-85-7
(3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 207856-85-7
(3S)-1-methylpyrrolidin-3-yl (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid / hexane / 5 h / 36 °C

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 16 h / -78 - 20 °C

3.1: potassium hydroxide; water / methanol / 4 h / 65 °C

4.1: 1,1'-carbonyldiimidazole / toluene

With trifluorormethanesulfonic acid; water; 1,1'-carbonyldiimidazole; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; toluene;