N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide

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Chemical Name:N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide
CAS No.:1337930-83-2
Molecular Formula:C₃₂H₃₅Cl₂N₇O₄
Molecular Weight:652.58
Hs Code.:

Synonyms:N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide

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Chemical Property of N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide

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Technology Process of N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide

There total 5 articles about N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1337932-16-7
N-(4-((4-amino-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide

: 530-62-1
1,1'-carbonyldiimidazole

: 227623-26-9
3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-amine

: 1337930-83-2
N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide

Guidance literature:: 1,1'-carbonyldiimidazole; 3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-amine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

N-(4-((4-amino-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 4h;

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 105250-17-7
2-amino-4-hydroxymethylpyridine

: 1337930-83-2
N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 2.25 h / 0 - 20 °C / Inert atmosphere

2.2: 25 h / 0 - 20 °C

2.3: 0.5 h

3.1: acetic acid; iron / 1.5 h / 60 °C

4.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

4.2: 4 h / 0 - 20 °C

With iron; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 36556-51-1
2,3-dichloro-1-fluoro-4-nitrobenzene

: 1337930-83-2
N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 2.25 h / 0 - 20 °C / Inert atmosphere

2.2: 25 h / 0 - 20 °C

2.3: 0.5 h

3.1: acetic acid; iron / 1.5 h / 60 °C

4.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

4.2: 4 h / 0 - 20 °C

With iron; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;