7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

Base Information

Chemical Name:7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate
CAS No.:1390655-13-6
Molecular Formula:C₂HF₃O₂*C₂₅H₂₄Cl₂N₆O₂
Molecular Weight:625.435
Hs Code.:

Synonyms:7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

Suppliers and Price of 7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

There total 9 articles about 7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390656-52-6
tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-4-hydroxypyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1390655-13-6
7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

Guidance literature:: tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-4-hydroxypyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate; With hydrogenchloride; water; In methanol;

With sodium hydrogencarbonate; In methanol; water;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 1390655-13-6
7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3.67 h / -78 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 30 h / 130 °C / Sealed tube

3.1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 70 °C / Inert atmosphere

4.1: hydrogenchloride; water / methanol

With hydrogenchloride; n-butyllithium; water; diisopropylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1246532-96-6
tert-butyl 4-(4-amino-3-methoxy-phenyl)-piperazine-1-carboxylate

: 1390655-13-6
7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4-ol mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 30 h / 130 °C / Sealed tube

2: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 70 °C / Inert atmosphere

3: hydrogenchloride; water / methanol

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;