(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride

Base Information

• Chemical Name: (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride
• CAS No.: 1335122-55-8
• Molecular Formula: C₁₅H₂₄IN₃O₂*ClH
• Molecular Weight: 441.74
• Mol file: 1335122-55-8.mol

Synonyms:(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride

Chemical Property of (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride

There total 8 articles about (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C25H40IN3O6 (1335122-60-5) → (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride (1335122-55-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 8h;

DOI:10.1016/j.bmc.2011.07.008

Reference yield:

C25H40N4O8 (1186120-60-4) → (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride (1335122-55-8)

Guidance literature:

Multi-step reaction with 3 steps

1: iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate / methanol / 3 h / Reflux

2: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0.67 h / 10 - 20 °C

3: hydrogenchloride / ethyl acetate / 8 h / 20 °C

With hydrogenchloride; iron(III) chloride hexahydrate; pyrographite; toluene-4-sulfonic acid; hydrazine hydrate; potassium iodide; sodium nitrite; In methanol; water; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmc.2011.07.008

Reference yield:

C25H42N4O6 (1335122-72-9) → (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride (1335122-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0.67 h / 10 - 20 °C

2: hydrogenchloride / ethyl acetate / 8 h / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In water; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmc.2011.07.008

upstream raw materials:

C₂₅H₄₀N₄O₈

C₂₅H₄₂N₄O₆

C₂₅H₄₀IN₃O₆

tert-butyl (1S,2R)-3-bromo-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate