4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Base Information

Chemical Name:4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester
CAS No.:167853-84-1
Molecular Formula:C₁₄H₁₅IN₂O₄
Molecular Weight:402.189
Hs Code.:

Synonyms:4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

There total 1 articles about 4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7631-86-9,105269-70-3,1317-48-2,13778-37-5,14464-46-1,14808-60-7,14832-85-0,15468-32-3,17679-64-0,87347-84-0,92283-58-4,99439-28-8,15723-40-7
SiO₂

: 167853-84-1
4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

Guidance literature:

Reference yield: 80.0%

: 3032-92-6
4-cyanophenylacetylene

: 167853-84-1
4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

: 201552-72-9
7-[[4-cyanophenyl]ethynyl]-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione-4-propanoic acid ethyl ester

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In ethyl acetate; at 20 ℃; for 1.25h;
DOI:10.1016/S0968-0896(98)80013-8

Reference yield:

: 167853-84-1
4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

: 167853-94-3
8-[[4-cyanophenyl]ethynyl]-1-methyl-6-oxo-4H-imidazo[1,2-a][1,4]benzodiazepine-5(6H)-propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / Lawesson's reagent / tetrahydrofuran / 2 h / 50 °C

2: 82 percent / tetrabutylammonium hydrogen sulfate; sodium hydroxide / CH₂Cl₂; H₂O / 16 h / 20 °C

3: 66 percent / pyridinium hydrochloride / toluene / 5 h / Heating

4: 78 percent / copper iodide; triethylamine / bis(triphenylphosphine)palladium dichloride / ethyl acetate / 20 °C

With Lawessons reagent; sodium hydroxide; copper(l) iodide; tetra(n-butyl)ammonium hydrogensulfate; pyridine hydrochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene; 1: Substitution / 2: Methylation / 3: Cyclization / 4: Heck coupling;
DOI:10.1016/S0968-0896(98)80013-8