(E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

Base Information

Chemical Name:(E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol
CAS No.:168960-76-7
Molecular Formula:C₄₁H₆₆O₇Si
Molecular Weight:699.056
Hs Code.:

Synonyms:(E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

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Chemical Property of (E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

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Technology Process of (E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

There total 19 articles about (E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 148933-56-6
(2S,3R,4R,6S)-2-Methoxy-3-(4-methoxy-benzyloxy)-4,6-dimethyl-oct-7-enal

: 148933-57-7
tert-Butyl-[(E)-(3S,4R)-6-iodo-3-(4-methoxy-benzyloxy)-4-methyl-hept-5-enyloxy]-dimethyl-silane

: 148933-72-6
(E)-(3S,4R,7R,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

: 168960-76-7
(E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

Guidance literature:: With chromium dichloride; nickel dichloride; In dimethyl sulfoxide; at 25 ℃; for 72h;

Reference yield: 9.0%

: (E)-(3S,4R,8S,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-one

: 148933-72-6
(E)-(3S,4R,7R,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

: 168960-76-7
(E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; at -78 ℃; for 1h;

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 168960-76-7
(E)-(3S,4R,7S,8R,9R,10R,12S)-1-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-3,9-bis-(4-methoxy-benzyloxy)-4,6,10,12-tetramethyl-tetradeca-5,13-dien-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / CSA / CH₂Cl₂ / 4 h / 25 °C

2: 96 percent / DIBALH / CH₂Cl₂ / 2 h / 25 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) r.t., 90 min

4: 26 percent / CrCl₂, NiCl₂ / dimethylsulfoxide / 72 h / 25 °C

With chromium dichloride; oxalyl dichloride; camphor-10-sulfonic acid; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; nickel dichloride; In dichloromethane; dimethyl sulfoxide;