N^2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N^1.3,N^1.3-(tetramethylene)amide

Base Information

• Chemical Name: N^2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N^1.3,N^1.3-(tetramethylene)amide
• CAS No.: 144732-01-4
• Molecular Formula: C₄₂H₄₆N₄O₆
• Molecular Weight: 702.85

Synonyms:N^2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N^1.3,N^1.3-(tetramethylene)amide

Chemical Property of N^2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N^1.3,N^1.3-(tetramethylene)amide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of N^2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N^1.3,N^1.3-(tetramethylene)amide

There total 7 articles about N^2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N^1.3,N^1.3-(tetramethylene)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-one (2472-13-1) → N2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N1.3,N1.3-(tetramethylene)amide (144732-01-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 84.9 percent / (NH₄)2CO₃ / ethanol; H₂O / 18 h / 80 °C

2: 83.2 percent / Ba(OH)2 / H₂O / 24 h / 125 °C

3: 85 percent / aq. NaOH / 2 h / Ambient temperature

4: DCC / CH₂Cl₂ / 3 h / Ambient temperature

5: dimethylformamide / 24 h / 50 °C

With barium dihydroxide; sodium hydroxide; ammonium carbonate; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19920750522

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → N2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N1.3,N1.3-(tetramethylene)amide (144732-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) CH₂Cl₂, 0 deg C, 30 min., 2.) CH₂Cl₂, 0 deg C, 30 min., r.t., 2 h

2: 82 percent / CF₃COOH / 4 h / 0 °C

3: dimethylformamide / 24 h / 50 °C

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19920750522

Reference yield:

2-amino-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carboxylic acid (35485-67-7) → N2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carbonyl>-L-phenylalanyl-L-phenylalanine N1.3,N1.3-(tetramethylene)amide (144732-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / aq. NaOH / 2 h / Ambient temperature

2: DCC / CH₂Cl₂ / 3 h / Ambient temperature

3: dimethylformamide / 24 h / 50 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19920750522

upstream raw materials:

L-phenylalanyl-L-phenylalanine N^1.2,N^1.2-(tetramethylene)amide

6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-one

N-tert-butoxycarbonyl-L-phenylalanine

2-amino-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carboxylic acid

Downstream raw materials:

(S)-methyl 2-benzamido-1,2,3,4-tetrahydro-6,7-dimethoxynaphthalene-2-carboxylate

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