3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol

Base Information

Chemical Name:3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol
CAS No.:263344-78-1
Molecular Formula:C₂₄H₁₉F₇N₂O₅
Molecular Weight:548.414
Hs Code.:

Synonyms:3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol

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Chemical Property of 3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol

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Technology Process of 3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol

There total 3 articles about 3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 586-78-7
para-nitrophenyl bromide

: 263344-11-2
(2R)-3-[[[3-(1,1,2,2-tetrafluoroethoxy]phenyl]methyl][3,3,3-trifluoro-2-hydroxy-propyl)amino]-phenol

: 263344-78-1
3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol

Guidance literature:: With 1-naphthalenecarboxylic acid; copper(II) bis(trifluoromethanesulfonate); caesium carbonate; In ethyl acetate; toluene; at 95 ℃;
DOI:10.1021/jm020528+

Reference yield:

: 35295-35-3
3-(1,1,2,2-Tetrafluoroethoxy)-benzaldehyde

: 263344-78-1
3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 6 h / 20 °C

2: 89 percent / Yb(OTf)3 / acetonitrile / 16 h / 50 °C

3: 11 percent / Cs₂CO₃; Cu(SO₃CF₃)2*C₆H₆; 1-naphthoic acid / toluene; ethyl acetate / 95 °C

With 1-naphthalenecarboxylic acid; copper(II) bis(trifluoromethanesulfonate); sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; ytterbium(III) triflate; In ethyl acetate; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jm020528+

Reference yield:

: 591-27-5
m-Hydroxyaniline

: 263344-78-1
3-[[3-(4-nitrophenoxy)phenyl][[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-methyl]amino]-1,1,1-trifluoro-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 6 h / 20 °C

2: 89 percent / Yb(OTf)3 / acetonitrile / 16 h / 50 °C

3: 11 percent / Cs₂CO₃; Cu(SO₃CF₃)2*C₆H₆; 1-naphthoic acid / toluene; ethyl acetate / 95 °C

With 1-naphthalenecarboxylic acid; copper(II) bis(trifluoromethanesulfonate); sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; ytterbium(III) triflate; In ethyl acetate; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jm020528+