[4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine

Base Information

Chemical Name:[4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine
CAS No.:1312603-65-8
Molecular Formula:C₃₁H₃₈N₄O₄
Molecular Weight:530.667
Hs Code.:

Synonyms:[4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine

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Chemical Property of [4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine

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Technology Process of [4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine

There total 9 articles about [4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 937273-33-1
3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenylamine

: 1107660-23-0
4-(3-allyloxymethyl-4-methoxyphenyl)-2-chloropyrimidine

: 1312603-65-8
[4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine

Guidance literature:: With hydrogenchloride; In water; butan-1-ol; at 80 ℃; for 4h;
DOI:10.1021/jm200326p

Reference yield:

: 2460-58-4
2-hydroxy-4-nitrobenzaldehyde

: 1312603-65-8
[4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 - 105 °C

2: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C

3: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / 12 h / 20 °C

4: N,N-dimethyl acetamide / 20 h / 90 °C

5: iron; ammonium chloride / ethanol; water / 4 h / 50 - 80 °C

6: hydrogenchloride / water; butan-1-ol / 4 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; iron; potassium carbonate; ammonium chloride; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jm200326p

Reference yield:

: 110837-53-1
2-(2-chloroethoxy)-5-nitrobenzaldehyde

: 1312603-65-8
[4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C

2: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / 12 h / 20 °C

3: N,N-dimethyl acetamide / 20 h / 90 °C

4: iron; ammonium chloride / ethanol; water / 4 h / 50 - 80 °C

5: hydrogenchloride / water; butan-1-ol / 4 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; iron; ammonium chloride; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water; butan-1-ol;
DOI:10.1021/jm200326p