3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide

Base Information

Chemical Name:3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide
CAS No.:1612842-14-4
Molecular Formula:C₂₁H₁₈ClFN₄O₅S
Molecular Weight:492.915
Hs Code.:

Synonyms:3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide

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Chemical Property of 3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide

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Technology Process of 3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide

There total 3 articles about 3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025721-01-0
4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide

: 78374-09-1
p-Tolylsulfamoyl-acetic acid

: 1612842-14-4
3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.04.056

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1612842-14-4
3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: potassium hydroxide / methanol; water / 3 h / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.ejmech.2014.04.056

Reference yield:

: 78374-64-8
ethyl 2-(N-p-tolylsulfamoyl)acetate

: 1612842-14-4
3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol; water / 3 h / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.ejmech.2014.04.056