(3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione

Base Information

• Chemical Name: (3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione
• CAS No.: 1268604-45-0
• Molecular Formula: C₂₈H₂₃N₃O₄
• Molecular Weight: 465.508
• Mol file: 1268604-45-0.mol

Synonyms:(3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione

Chemical Property of (3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione

There total 7 articles about (3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(Z)-1-acetyl-3-((5-(2-methylpent-4-yn-2yl)oxazol-4-yl)methylene)piperazine-2,5-dione (1268604-44-9) + 3-benzoylbenzaldehyde (71856-95-6) → (3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione (1268604-45-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.10.055

Reference yield:

C10H13NO2 (1268604-41-6) → (3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione (1268604-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: manganese(IV) oxide / acetone / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

With manganese(IV) oxide; caesium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmc.2010.10.055

Reference yield:

3-benzoylbenzoic acid (579-18-0) → (3Z,6Z)-3-(3-benzoylbenzylidene)-6-((5-(2-methyl-pent-4-yn-2-yl)oxazol-4-yl)methylene)piperazine-2,5-dione (1268604-45-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

3: Dess-Martin periodane / tetrahydrofuran / 2 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

With lithium aluminium tetrahydride; caesium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Dess-Martin oxidation;

DOI:10.1016/j.bmc.2010.10.055

upstream raw materials:

C₁₀H₁₃NO₂

ethyl 5-(2-methylpent-4-yn-2-yl)oxazole-4-carboxylate

5-(2-methylpent-4-yn-2-yl)oxazole-4-carboaldehyde

3-benzoyl-N-methoxy-N-methylbenzamide

Downstream raw materials:

KPU-252-B₁