4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Base Information

• Chemical Name: 4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile
• CAS No.: 183882-20-4
• Molecular Formula: C₂₈H₂₅N₅O₅
• Molecular Weight: 511.537
• Mol file: 183882-20-4.mol

Synonyms:4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Chemical Property of 4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile

There total 2 articles about 4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.9%

4-amino-6-bromo-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile (183882-19-1) → 4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile (183882-20-4)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; at 50 ℃; for 4h; under 2585.7 Torr;

DOI:10.1021/ja961540s

Reference yield:

2-[(ethoxymethylene)amino]-5-bromo-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrole-3,4-dicarbonitrile → 4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile (183882-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NH₃ / methanol / -78 - 4 °C

2: 79.9 percent / H₂, Et₃N / 10percent Pd/C / dioxane / 4 h / 50 °C / 2585.7 Torr

With ammonia; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol;

DOI:10.1021/ja961540s

Reference yield:

4-amino-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile (183882-20-4) → C28H26N4O6

Guidance literature:

With pyridine; sodium hypophosphite; nickel; acetic acid; isobutyric Acid; at 55 - 65 ℃; for 6h;

DOI:10.1021/ja961540s

upstream raw materials:

4-amino-6-bromo-7-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carbonitrile