(2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol

Base Information

Chemical Name:(2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol
CAS No.:887769-14-4
Molecular Formula:C₄₉H₇₂O₇Si₂
Molecular Weight:829.277
Hs Code.:

Synonyms:(2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol

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Chemical Property of (2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol

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Technology Process of (2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol

There total 16 articles about (2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 864712-70-9
(2S,3S,4S,5R,6R)-methyl 4,5-bis(benzyloxy)-12-t-butyldiphenylsiloxy-6-triethylsiloxy-2,3-dihydroxy-6-methyldodecanoate

: 887769-14-4
(2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1246/bcsj.79.468

Reference yield:

: 864712-67-4
(2R,3R,4R)-2,3-bis(benzyloxy)-10-t-butyldiphenylsiloxy-4-triethylsiloxy-4-methyldecanal

: 887769-14-4
(2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / benzene / 13 h / 100 °C

2: 100 percent / N-methylmorpholine N-oxide / OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 40 h / 0 - 20 °C

3: 100 percent / LiBH₄ / tetrahydrofuran / 2 h / 0 °C

With lithium borohydride; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In tetrahydrofuran; water; acetone; tert-butyl alcohol; benzene; 1: Wittig reaction;
DOI:10.1246/bcsj.79.468

Reference yield:

: 887768-95-8
(E,4S,5R,6R)-methyl 4,5-bis(benzyloxy)-12-t-butyldiphenylsiloxy-6-triethylsiloxy-6-methyldodec-2-enoate

: 887769-14-4
(2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-triethylsilanyloxy-dodecane-1,2,3-triol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / N-methylmorpholine N-oxide / OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 40 h / 0 - 20 °C

2: 100 percent / LiBH₄ / tetrahydrofuran / 2 h / 0 °C

With lithium borohydride; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In tetrahydrofuran; water; acetone; tert-butyl alcohol;
DOI:10.1246/bcsj.79.468