3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride

Base Information

• Chemical Name: 3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride
• CAS No.: 117291-35-7
• Molecular Formula: C₁₃H₁₃ClF₃NO₂
• Molecular Weight: 307.7
• Mol file: 117291-35-7.mol

Synonyms:3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride

Chemical Property of 3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride

There total 4 articles about 3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionic acid (117291-17-5) → 3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride (117291-35-7)

Guidance literature:

With thionyl chloride; for 0.5h; Heating;

DOI:10.1016/0223-5234(92)90029-Z

Reference yield:

4-ethylbenzylaldehyde (4748-78-1) → 3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride (117291-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / AcONH₄ / ethanol / 6 h / Heating

2: 85 percent / 0.5 h / Ambient temperature

3: 95 percent / SOCl₂ / 0.5 h / Heating

With thionyl chloride; ammonium acetate; In ethanol;

DOI:10.1016/0223-5234(92)90029-Z

Reference yield:

3-amino-3-(4-ethyl-phenyl)-propionic acid (117391-52-3) → 3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride (117291-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 0.5 h / Heating

2: thionyl chloride / benzene / 0.5 h / Heating

With thionyl chloride; trifluoroacetic acid; In benzene;

upstream raw materials:

3-(4-Ethyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionic acid

3-amino-3-(4-ethyl-phenyl)-propionic acid

4-ethylbenzylaldehyde