(S)-2,3,6,7-Tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one

Base Information

• Chemical Name: (S)-2,3,6,7-Tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
• CAS No.: 99746-73-3
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.256
• Mol file: 99746-73-3.mol

Synonyms:(S)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Chemical Property of (S)-2,3,6,7-Tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one

Chemical Property:

• Solubility.: Chloroform; Dichloromethane; Methanol

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: L-Praziquanamine is an intermediate in the synthesis of Unlabeled (S)-Praziquante-d11 (P702105), used in the synthetic preparation of perphenylcarbamated β-cyclodextrin based chiral stationary phases via thiol-ene click chemistry for HPLC enantioseparations. (S)-Praziquantel is also the inactive enantiomer of praziquantel regarding activity against juvenile S. mansoni infestations in mice.

Technology Process of (S)-2,3,6,7-Tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one

There total 10 articles about (S)-2,3,6,7-Tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C12H14N2O*C4H6O6 → (S)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one (99746-73-3,55375-90-1)

Guidance literature:

With sodium hydroxide; In water; pH=12;

DOI:10.1016/j.bmcl.2014.07.039

Reference yield: 96.9%

(S)-praziquanamine-hemi-dibenzoyl-D-tataric acid salt (1622136-46-2,1399880-37-5) → (S)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one (99746-73-3,55375-90-1)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; for 0.5h;

Reference yield: 88.0%

(S)-(+)-2-((S)-2-(6-methoxynaphthalen-2-yl)propanoyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one (1558003-70-5) → (S)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one (99746-73-3,55375-90-1)

Guidance literature:

With phosphoric acid; In water; at 150 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1016/j.tetasy.2013.11.004

upstream raw materials:

C₂₂H₂₁F₃N₂O₃

2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one

(S)-(+)-2-((S)-2-(6-methoxynaphthalen-2-yl)propanoyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one

Downstream raw materials:

(+)-2-(4-oxocyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

(-)-1,3,4,6,7,11b-Hexahydro-2H-pyrazino<2,1-a>isochinolin

(+)-1,3,4,6,7,11b-Hexahydro-2H-pyrazino<2,1-a>isochinolin

(+)-2-(4-trans-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one