cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

Base Information

• Chemical Name: cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate
• CAS No.: 452914-70-4
• Molecular Formula: C₅₆H₈₇N₄O₁₄P
• Molecular Weight: 1071.3
• Mol file: 452914-70-4.mol

Synonyms:cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

Chemical Property of cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

There total 4 articles about cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

({1-({[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-methyl)-2-[(2-cyano-ethoxy)-(4,4-diphenyl-cyclohexyloxy)-phosphanyloxy]-ethyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester → cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate (452914-70-4)

Guidance literature:

With tert.-butylhydroperoxide; In acetonitrile; at 20 ℃; for 1.5h;

DOI:10.1021/jm0102351

Reference yield:

4,4-diphenyl-cyclohexanol (42420-85-9) → cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate (452914-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / acetonitrile / 20 °C

2: t-BuOOH / acetonitrile / 1.5 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; In acetonitrile;

DOI:10.1021/jm0102351

Reference yield:

2-(R)-hydroxymethyldiethylenetriamine-N,N,N',N'',N''-pentaacetato-penta-tert-butyl ester (178761-55-2) → cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate (452914-70-4)

Guidance literature:

Multi-step reaction with 3 steps

1: iPr₂NEt / CH₂Cl₂ / 2 h / 20 °C

2: 1H-tetrazole / acetonitrile / 20 °C

3: t-BuOOH / acetonitrile / 1.5 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1021/jm0102351

upstream raw materials:

4,4-diphenyl-cyclohexanol

2-(R)-hydroxymethyldiethylenetriamine-N,N,N',N'',N''-pentaacetato-penta-tert-butyl ester

({2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-1-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxymethyl]-ethyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester