cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

Base Information

Chemical Name:cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate
CAS No.:452914-70-4
Molecular Formula:C₅₆H₈₇N₄O₁₄P
Molecular Weight:1071.3
Hs Code.:

Synonyms:cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

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Technology Process of cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

There total 4 articles about cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ({1-({[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-methyl)-2-[(2-cyano-ethoxy)-(4,4-diphenyl-cyclohexyloxy)-phosphanyloxy]-ethyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester

: 452914-70-4
cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

Guidance literature:: With tert.-butylhydroperoxide; In acetonitrile; at 20 ℃; for 1.5h;
DOI:10.1021/jm0102351

Reference yield:

: 42420-85-9
4,4-diphenyl-cyclohexanol

: 452914-70-4
cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-tetrazole / acetonitrile / 20 °C

2: t-BuOOH / acetonitrile / 1.5 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; In acetonitrile;
DOI:10.1021/jm0102351

Reference yield:

: 178761-55-2
2-(R)-hydroxymethyldiethylenetriamine-N,N,N',N'',N''-pentaacetato-penta-tert-butyl ester

: 452914-70-4
cyanoethyl-(4,4-diphenylcyclohexyl)-(R)-phosphonooxymethyl-penta-tert-butyl-diethylenetriaminepentaacetate

Guidance literature:: Multi-step reaction with 3 steps

1: iPr₂NEt / CH₂Cl₂ / 2 h / 20 °C

2: 1H-tetrazole / acetonitrile / 20 °C

3: t-BuOOH / acetonitrile / 1.5 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm0102351