(R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone

Base Information

Chemical Name:(R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone
CAS No.:194656-60-5
Molecular Formula:C₁₈H₃₃NO₃Si
Molecular Weight:339.55
Hs Code.:

Synonyms:(R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone

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Technology Process of (R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone

There total 1 articles about (R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 194656-44-5
(R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexa-2,5-dienone

: 194656-60-5
(R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 5h; under 3258.03 Torr;
DOI:10.1021/jo9707592

Reference yield: 93.0%

: 194656-60-5
(R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone

: 194656-54-7
(S)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-cyclohex-2-enone

Guidance literature:: With copper dichloride; In N,N-dimethyl-formamide; at 60 ℃; for 1h;
DOI:10.1021/jo9707592

Reference yield:

: 194656-60-5
(R)-4-Ethyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexanone

: 4880-88-0
vinburnine

Guidance literature:: Multi-step reaction with 9 steps

1: 81 percent / m-CPBA / CH₂Cl₂ / 36 h

2: TsOH*H₂O / benzene; H₂O / 24 h / Heating

3: 71 percent / Et₃N, (PhO)2P(O)N₃ / tetrahydrofuran / Ambient temperature

4: 84 percent / LiBH₄ / methanol; tetrahydrofuran / 48 h / Ambient temperature

5: 84 percent / KH / tetrahydrofuran / 3 h / Ambient temperature

6: 70 percent / molecular sieves, NMO, TPAP / CH₂Cl₂ / 2 h / Ambient temperature

7: 88 percent / CF₃CO₂H / CH₂Cl₂ / 10 h / -55 °C

8: 1.) BH₃, 2.) 6 N NaOH, H₂O₂ / 1.) THF, room temperature, 2 h, 2.) EtOH, H₂O, 55 deg C, 1.5 h

9: 97 percent / molecular sieves, NMO, TPAP / CH₂Cl₂ / 1 h

With sodium hydroxide; lithium borohydride; N-methyl-2-indolinone; molecular sieve; tetrapropylammonium perruthennate; diphenyl phosphoryl azide; borane; dihydrogen peroxide; potassium hydride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1021/jo9707592