(S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester

Base Information

Chemical Name:(S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester
CAS No.:910576-39-5
Molecular Formula:C₁₃H₁₂ClF₃O₅
Molecular Weight:340.683
Hs Code.:

Synonyms:(S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester

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Chemical Property of (S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester

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Technology Process of (S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester

There total 2 articles about (S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 910576-40-8
2-[1-(3-chloro-4-hydroxy-5-trifluoromethyl-phenyl)-meth(Z)-ylidene]-succinic acid 1-methyl ester

: 910576-39-5
(S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester

Guidance literature:: 2-[1-(3-chloro-4-hydroxy-5-trifluoromethyl-phenyl)-meth(Z)-ylidene]-succinic acid 1-methyl ester; With hydrogen; (Z,Z)-cycloocta-1,5-diene(R,R-1,2-bis(2,5-diethylphospholanyl)benzene)rhodium(I) tetrafluoroborate; In methanol; triethylamine; at 20 ℃; for 8h; under 37503.8 Torr;

With hydrogenchloride; In water; ethyl acetate;

Reference yield: 74.0%

: 910576-39-5
(S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester

Guidance literature:

Reference yield: 65.0%

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: 910576-39-5
(S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester

: 910575-96-1
(S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidin-1-yl]-butanoic acid methyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 12h;