2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid

Base Information

• Chemical Name: 2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid
• CAS No.: 1402586-83-7
• Molecular Formula: C₁₀H₁₁FO₃
• Molecular Weight: 198.194
• Mol file: 1402586-83-7.mol

Synonyms:2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid

Chemical Property of 2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid

There total 5 articles about 2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

benzyl 2-(4-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluorophenyl)acrylate → 2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid (1402586-83-7)

Guidance literature:

With palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; at 20 ℃; for 16h;

Reference yield:

(4-bromo-2-fluorophenyl)methoxy-tert-butyldimethylsilane (930785-23-2) → 2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid (1402586-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium acetate; caesium carbonate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

4-bromo-2-fluorobenzaldehyde (57848-46-1) → 2-(3-fluoro-4-(hydroxymethyl)phenyl)propanoic acid (1402586-83-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium tetrahydroborate; methanol / 1 h / -5 - 20 °C

2: 1H-imidazole / dichloromethane / 1 h / 20 °C

3: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 16 h / 20 °C

With 1H-imidazole; methanol; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium acetate; caesium carbonate; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-bromo-2-fluorobenzyl alcohol

(4-bromo-2-fluorophenyl)methoxy-tert-butyldimethylsilane

4-bromo-2-fluorobenzaldehyde

Downstream raw materials:

2-[3-fluoro-4-(hydroxymethyl)phenyl]-N-[[2-(4-fluorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]propionamide