methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate

Base Information

Chemical Name:methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate
CAS No.:124749-75-3
Molecular Formula:C₃₂H₃₂ClF₃N₄O₅S
Molecular Weight:677.144
Hs Code.:

methyl 2-n-butyl-4-chloro-1-<<4-<N-(phenylmethyl)-N-<2-(trifluoromethanesulfonamido)benzoyl>amino>phenyl>methyl>imidazole-5-acetate

Synonyms:methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate

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Chemical Property of methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate

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Technology Process of methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate

There total 10 articles about methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 80798-76-1
N-(trifluoromethanesulfonyl)anthranilic acid chloride

: 115444-48-9
methyl 2-n-butyl-4-chloro-1-<<4-(N-(phenylmethyl)amino)phenyl>methyl>imidazole-5-acetate

: 124749-75-3
methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 25 ℃;
DOI:10.1021/jm00167a007

Reference yield:

: 114799-92-7
2-Butyl-4-chloro-1-[(4-nitrophenyl)methyl]-1H-imidazole-5-methanol

: 124749-75-3
methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / CHCl₃ / 2 h / 0 - 20 °C

2: dimethylsulfoxide

3: 98 percent / 12 N HCl, glacial acetic acid / 6 h / Heating

4: 71 percent / 3.1 M HCl / dioxane / 7.5 h / Heating

5: 98 percent / iron, glacial acetic acid / methanol / 5.5 h / Heating

6: 4 Angstroem molecular sieves, Al₂O₃ / tetrahydrofuran / Ambient temperature

7: sodium cyanoborohydride / methanol / 24 h

8: 81 percent / NaHCO₃ / CH₂Cl₂ / 25 °C

With hydrogenchloride; aluminum oxide; thionyl chloride; 4 A molecular sieve; iron; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00167a007

Reference yield:

: 125665-56-7
2-Butyl-4-chloro-5-chloromethyl-1-(4-nitro-benzyl)-1H-imidazole

: 124749-75-3
methyl 2-n-butyl-4-chloro-1-<<4-amino>phenyl>methyl>imidazole-5-acetate

Guidance literature:: Multi-step reaction with 7 steps

1: dimethylsulfoxide

2: 98 percent / 12 N HCl, glacial acetic acid / 6 h / Heating

3: 71 percent / 3.1 M HCl / dioxane / 7.5 h / Heating

4: 98 percent / iron, glacial acetic acid / methanol / 5.5 h / Heating

5: 4 Angstroem molecular sieves, Al₂O₃ / tetrahydrofuran / Ambient temperature

6: sodium cyanoborohydride / methanol / 24 h

7: 81 percent / NaHCO₃ / CH₂Cl₂ / 25 °C

With hydrogenchloride; aluminum oxide; 4 A molecular sieve; iron; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00167a007