1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride

Base Information

Chemical Name:1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride
CAS No.:76924-99-7
Molecular Formula:C₂₃H₃₁N₃O₆*2ClH
Molecular Weight:518.438
Hs Code.:

Synonyms:1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride

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Chemical Property of 1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride

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Technology Process of 1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride

There total 3 articles about 1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 76925-18-3
1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-one; hydrochloride

: 76924-99-7
1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride

Guidance literature:: With sodium tetrahydroborate; In methanol; for 2h; Ambient temperature;
DOI:10.1248/cpb.35.2774

Reference yield:

: 13171-25-0,127881-54-3
trimetazidine dihydrochloride

: 76924-99-7
1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: nitromethane / 4.5 h / Heating

2: 89 percent / sodium borohydride (NaBH₄) / methanol / 2 h / Ambient temperature

With sodium tetrahydroborate; In methanol; nitromethane;
DOI:10.1248/cpb.35.2774

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 76924-99-7
1-(4-Nitro-phenyl)-3-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-propan-1-ol; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: nitromethane / 4.5 h / Heating

2: 89 percent / sodium borohydride (NaBH₄) / methanol / 2 h / Ambient temperature

With sodium tetrahydroborate; In methanol; nitromethane;
DOI:10.1248/cpb.35.2774