tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate
CAS No.:1005195-57-2
Molecular Formula:C₃₂H₃₃ClN₆O₄
Molecular Weight:601.105
Hs Code.:

Synonyms:tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193085-24-4
4-carboxymethylenepiperidine-1-carboxylic acid tert-butyl ester

: 179688-74-5
N⁴-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)quinazoline-4,6-diamine

: 1005195-57-2
tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate

Guidance literature:: 4-carboxymethylenepiperidine-1-carboxylic acid tert-butyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; for 0.333333h; Cooling with salt-ice bath;

N⁴-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)quinazoline-4,6-diamine; With 4-methyl-morpholine; pyridine; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1005195-57-2
tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate; sodium chloride / tetrahydrofuran; water / 20 °C

2.1: sodium hydroxide / ethanol / 0.5 h / 20 °C

2.2: 20 °C

2.3: pH 4

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

3.2: pH 4

4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

4.2: 0 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydroxide; water; sodium hydrogencarbonate; sodium chloride; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1005195-57-2
tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) quinazolin-6-ylamino)-2-oxoethylidene) piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol / 0.5 h / 20 °C

1.2: 20 °C

1.3: pH 4

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

2.2: pH 4

3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

3.2: 0 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydroxide; water; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol;