(R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Base Information

Chemical Name:(R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide
CAS No.:233749-50-3
Molecular Formula:C₃₄H₄₅N₅O₈
Molecular Weight:651.76
Hs Code.:

(R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Synonyms:(R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

There total 6 articles about (R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: phthalimidoacetaldehyde hydrate

: 233749-19-4
N²-[4-(N-2,4-dimethoxybenzyloxyamino)-2R-isobutyl-3S-aminosuccinyl]-L-tert-leucine-N¹-methylamide

: 233749-50-3
(R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Guidance literature:: With trimethyl orthoformate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(99)00347-6

Reference yield:

: 89226-12-0
(S)-2-amino-N,3,3-trimethylbutanamide

: 233749-50-3
(R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 4.0 g / EDCI / CH₂Cl₂ / 3 h

2: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 18 h / 0 °C

3: 75 percent / EDCI / dimethylformamide / 18 h / 20 °C

4: 92 percent / piperidine / dimethylformamide / 1 h

5: 57 percent / trimethylorthoformate / CH₂Cl₂ / 2 h / 20 °C

With piperidine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; trimethyl orthoformate; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrolysis / 3: Condensation / 4: Hydrolysis / 5: Cyclization;
DOI:10.1016/S0040-4020(99)00347-6

Reference yield:

: 204126-52-3
3(R/S)-(9-fluorenylmethoxycarbonylamino)-2R-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

: 233749-50-3
(R)-2-[(S)-1-(2,4-Dimethoxy-benzyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-oxo-imidazolidin-4-yl]-4-methyl-pentanoic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 4.0 g / EDCI / CH₂Cl₂ / 3 h

2: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 18 h / 0 °C

3: 75 percent / EDCI / dimethylformamide / 18 h / 20 °C

4: 92 percent / piperidine / dimethylformamide / 1 h

5: 57 percent / trimethylorthoformate / CH₂Cl₂ / 2 h / 20 °C

With piperidine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; trimethyl orthoformate; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrolysis / 3: Condensation / 4: Hydrolysis / 5: Cyclization;
DOI:10.1016/S0040-4020(99)00347-6