2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid

Base Information

Chemical Name:2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid
CAS No.:1257388-11-6
Molecular Formula:C₂₂H₃₀N₂O₈
Molecular Weight:450.489
Hs Code.:

Synonyms:2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid

Suppliers and Price of 2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid

There total 8 articles about 2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1257388-09-2
tert-butyl 3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

: 1257388-11-6
2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid

Guidance literature:: With water; sodium hydroxide; In methanol;

Reference yield:

: 88664-38-4
ethyl 6-oxo-1,4-dioxepane-5-carboxylate

: 1257388-11-6
2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water / 2.5 h / Reflux

2.1: N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydroxide / dichloromethane / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 1 h / 20 °C

5.1: water; sodium hydroxide / methanol

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1257388-05-8
3-(3-methoxyphenyl-1)-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-5-one

: 1257388-11-6
2-(1-(tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]-dodecan-4-yl)ethanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 1 h / 20 °C

3.1: water; sodium hydroxide / methanol

With water; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;