[(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester
• CAS No.: 181314-38-5
• Molecular Formula: C₃₄H₄₈N₆O₅
• Molecular Weight: 620.792

Synonyms:[(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester

Chemical Property of [(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester

There total 14 articles about [(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (S)-[1-(benzylamino)-1-oxopropan-2-yl]carbamate (51814-55-2,140866-04-2) → [(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester (181314-38-5)

Guidance literature:

Multi-step reaction with 14 steps

1: 98 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

2: BH₃*THF / tetrahydrofuran / 22 h / Heating

3: CH₂Cl₂ / 16 h / 25 °C

4: 90 percent / 2,6-di-t-butyl-4-methyl pyridine / CH₂Cl₂ / 4 h / 25 °C

5: 60 percent / piperidine / CH₂Cl₂ / 1 h / 25 °C

6: BH₃*THF / tetrahydrofuran / 3 h / 60 °C

7: CH₂Cl₂ / 2.5 h / 25 °C

8: 100 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

9: BH₃*THF / tetrahydrofuran / 22 h / Heating

10: CH₂Cl₂ / 16 h / 25 °C

11: 73 percent / 2,6-di-t-butyl-4-methylpyridine / CH₂Cl₂ / 4 h / 25 °C

12: 60 percent / piperidine / CH₂Cl₂ / 1 h / 25 °C

13: BH₃*THF / tetrahydrofuran / 3 h / 60 °C

14: CH₂Cl₂ / 2.5 h / 25 °C

With piperidine; 2,6-di-tert-butyl-4-methylpyridine; borane-THF; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(96)01101-X

Reference yield:

(S)-2-amino-N-benzylpropanamide (75040-72-1) → [(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester (181314-38-5)

Guidance literature:

Multi-step reaction with 13 steps

1: BH₃*THF / tetrahydrofuran / 22 h / Heating

2: CH₂Cl₂ / 16 h / 25 °C

3: 90 percent / 2,6-di-t-butyl-4-methyl pyridine / CH₂Cl₂ / 4 h / 25 °C

4: 60 percent / piperidine / CH₂Cl₂ / 1 h / 25 °C

5: BH₃*THF / tetrahydrofuran / 3 h / 60 °C

6: CH₂Cl₂ / 2.5 h / 25 °C

7: 100 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

8: BH₃*THF / tetrahydrofuran / 22 h / Heating

9: CH₂Cl₂ / 16 h / 25 °C

10: 73 percent / 2,6-di-t-butyl-4-methylpyridine / CH₂Cl₂ / 4 h / 25 °C

11: 60 percent / piperidine / CH₂Cl₂ / 1 h / 25 °C

12: BH₃*THF / tetrahydrofuran / 3 h / 60 °C

13: CH₂Cl₂ / 2.5 h / 25 °C

With piperidine; 2,6-di-tert-butyl-4-methylpyridine; borane-THF; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(96)01101-X

Reference yield:

(S)-N1-benzyl-1,2-propanediamine (75040-69-6) → [(S)-1-(2-{(S)-5-Benzyl-3-[2-((S)-3-benzyl-5-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-2-oxo-imidazolidin-1-yl}-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester (181314-38-5)

Guidance literature:

Multi-step reaction with 12 steps

1: CH₂Cl₂ / 16 h / 25 °C

2: 90 percent / 2,6-di-t-butyl-4-methyl pyridine / CH₂Cl₂ / 4 h / 25 °C

3: 60 percent / piperidine / CH₂Cl₂ / 1 h / 25 °C

4: BH₃*THF / tetrahydrofuran / 3 h / 60 °C

5: CH₂Cl₂ / 2.5 h / 25 °C

6: 100 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

7: BH₃*THF / tetrahydrofuran / 22 h / Heating

8: CH₂Cl₂ / 16 h / 25 °C

9: 73 percent / 2,6-di-t-butyl-4-methylpyridine / CH₂Cl₂ / 4 h / 25 °C

10: 60 percent / piperidine / CH₂Cl₂ / 1 h / 25 °C

11: BH₃*THF / tetrahydrofuran / 3 h / 60 °C

12: CH₂Cl₂ / 2.5 h / 25 °C

With piperidine; 2,6-di-tert-butyl-4-methylpyridine; borane-THF; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(96)01101-X

upstream raw materials:

tert-butyl (S)-[1-(benzylamino)-1-oxopropan-2-yl]carbamate

(S)-2-amino-N-benzylpropanamide

(S)-N¹-benzyl-1,2-propanediamine

benzylamine

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