2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

Base Information

Chemical Name:2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile
CAS No.:1255700-54-9
Molecular Formula:C₂₅H₂₆N₈O
Molecular Weight:454.534
Hs Code.:

Synonyms:2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

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Chemical Property of 2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

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Technology Process of 2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

There total 6 articles about 2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1255701-49-5
2-(8-chloro-2-(1,3-dimethyl-1H-pyrazol-5-yl)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

: 74852-81-6
4-(2-methyl-1H-imidazol-1-yl)benzenamine

: 1255700-54-9
2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

Guidance literature:: With caesium carbonate; palladium diacetate; In 1,2-dimethoxyethane; at 100 ℃; for 2h; Sealed microwave vial; Inert atmosphere;

Reference yield:

: 25016-09-5
1,3-dimethyl-1H-pyrazole-5-carbaldehyde

: 1255700-54-9
2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 0 - 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3.1: acetic acid / methanol / 0 - 20 °C

3.2: 0.17 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

5.1: triethylamine / tetrahydrofuran / 20 °C

6.1: caesium carbonate / palladium diacetate / 1,2-dimethoxyethane / 2 h / 100 °C / Sealed microwave vial; Inert atmosphere

With ammonium formate; sodium hydride; caesium carbonate; acetic acid; triethylamine; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;

Reference yield:

: 1255701-52-0
2-amino-1-(1,3-dimethyl-1H-pyrazol-5-yl)ethanol

: 1255700-54-9
2-(2-(1,3-dimethyl-1H-pyrazol-5-yl)-8-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 0 - 20 °C

1.2: 0.17 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 20 °C

4.1: caesium carbonate / palladium diacetate / 1,2-dimethoxyethane / 2 h / 100 °C / Sealed microwave vial; Inert atmosphere

With sodium hydride; caesium carbonate; acetic acid; triethylamine; palladium diacetate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;