N-(2-Benzylaminoethyl)glycine Dihydrochloride

Base Information

• Chemical Name: N-(2-Benzylaminoethyl)glycine Dihydrochloride
• CAS No.: 63784-13-4
• Molecular Formula: C₁₁H₁₆N₂O₂*2ClH
• Molecular Weight: 281.182
• Mol file: 63784-13-4.mol

Synonyms:N-(2-Benzylaminoethyl)glycine Dihydrochloride

Chemical Property of N-(2-Benzylaminoethyl)glycine Dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Benzylaminoethyl)glycine Dihydrochloride

There total 4 articles about N-(2-Benzylaminoethyl)glycine Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-Benzyl-4-chloroacetyl-2-piperazinone (107235-76-7) → N-(2-Benzylaminoethyl)glycine Dihydrochloride (63784-13-4)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1007/BF00542783

Reference yield:

1-benzyl-piperazin-2-one (59702-21-5) → N-(2-Benzylaminoethyl)glycine Dihydrochloride (63784-13-4)

Guidance literature:

With hydrogenchloride; water; for 40h; Heating / reflux;

Reference yield:

N-Benzyl-N,N'-bis(chloroacetyl)ethylendiamine (107235-77-8) → N-(2-Benzylaminoethyl)glycine Dihydrochloride (63784-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / potassium tert-butylate / 2-methyl-propan-2-ol / 0.33 h / Ambient temperature

2: 92 percent / dilute hydrochloric acid (1:1) / 1 h / Heating

With hydrogenchloride; potassium tert-butylate; In tert-butyl alcohol;

DOI:10.1007/BF00542783

upstream raw materials:

1-Benzyl-4-chloroacetyl-2-piperazinone

N-Benzyl-N,N'-bis(chloroacetyl)ethylendiamine

N-benzylethylenediamine

1-benzyl-piperazin-2-one

Downstream raw materials:

1-carboxymethyl-3-benzyl-2-iminoimidazolidine

Refernces

• 1、 Tsizin, Yu.S.,Sergovskaya, N.L.,Chernyak, S.A.. "SYNTHESIS OF 1-ALKYL(ARALKYL)-4-ACYL-2-PIPERAZINONES". . p. 421 - 424. Retrieved 2007/10/02.