di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate

Base Information

Chemical Name:di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate
CAS No.:737823-46-0
Molecular Formula:C₂₄H₃₃N₅O₅S
Molecular Weight:503.623
Hs Code.:

Synonyms:di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate

Suppliers and Price of di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate

There total 5 articles about di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: N-{5-[2-(4-aminophenyl)ethyl]-1,3-thiazol-2-yl}acetamide

: 152120-54-2,862686-58-6,1143572-00-2
N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

: 737823-46-0
di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate

Guidance literature:: In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃; for 5.5h;
DOI:10.1016/j.bmc.2012.12.025

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 737823-46-0
di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C / Inert atmosphere

2: potassium tert-butylate / N,N-dimethyl-formamide / 14 h / 0 - 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide; ethyl acetate / 4 h / 20 °C / 3040.2 Torr

4: N,N-dimethyl-formamide; tetrahydrofuran / 5.5 h / 50 °C

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 2: |Wittig Olefination;
DOI:10.1016/j.bmc.2012.12.025

Reference yield:

: 2767-70-6
(p-nitrobenzyl)triphenylphosphonium bromide

: 737823-46-0
di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / N,N-dimethyl-formamide / 14 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide; ethyl acetate / 4 h / 20 °C / 3040.2 Torr

3: N,N-dimethyl-formamide; tetrahydrofuran / 5.5 h / 50 °C

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 1: |Wittig Olefination;
DOI:10.1016/j.bmc.2012.12.025