N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

Base Information

• Chemical Name: N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine
• CAS No.: 1187835-51-3
• Molecular Formula: C₁₆H₁₅N₇O₂
• Molecular Weight: 337.341
• Mol file: 1187835-51-3.mol

Synonyms:N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

Chemical Property of N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

There total 5 articles about N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridine-2-carbaldehyde (1187835-48-8) → N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine (1187835-51-3)

Guidance literature:

With pyridine; hydroxylamine hydrochloride;

Reference yield:

(6-[1,3]dioxolan-2-yl-pyridin-2-yl)methanol (208111-47-1) → N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine (1187835-51-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfurous dibromide / dichloromethane / 5 - 20 °C

2: DBN / acetonitrile / 0 - 20 °C

3: water; toluene-4-sulfonic acid / dimethyl sulfoxide / 1.5 h / 100 °C

4: pyridine; hydroxylamine hydrochloride

With pyridine; sulfurous dibromide; DBN; hydroxylamine hydrochloride; water; toluene-4-sulfonic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

2-[1,3]dioxolan-2-yl-6-methylpyridine 1-oxide (897943-12-3) → N-({6-[(hydroxyimino)methyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine (1187835-51-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h

1.2: 2 h

2.1: sulfurous dibromide / dichloromethane / 5 - 20 °C

3.1: DBN / acetonitrile / 0 - 20 °C

4.1: water; toluene-4-sulfonic acid / dimethyl sulfoxide / 1.5 h / 100 °C

5.1: pyridine; hydroxylamine hydrochloride

With pyridine; sulfurous dibromide; DBN; hydroxylamine hydrochloride; water; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;

upstream raw materials:

6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridine-2-carbaldehyde

6-methyl-2-pyridinecarboxaldehyde

2-[1,3]dioxolan-2-yl-6-methylpyridine 1-oxide

2-(1,3-dioxolan-2-yl)-6-methylpyridine

Downstream raw materials:

N-[(6-{[(cyclohexyloxy)imino]methyl}pyridin-2-yl)methoxy]-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine