7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride

Base Information

• Chemical Name: 7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride
• CAS No.: 138786-16-0
• Molecular Formula: C₁₈H₁₂ClN₅*ClH
• Molecular Weight: 370.241
• Mol file: 138786-16-0.mol

Synonyms:7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride

Chemical Property of 7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride

There total 3 articles about 7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-chloro-2-<2-(3-cyanophenyl)ethenyl>quinoline (138786-17-1) → 7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride (138786-16-0)

Guidance literature:

With lithium azide; triethylamine hydrobromide; In N,N-dimethyl-formamide; at 120 ℃; for 18h;

DOI:10.1021/jm00085a005

Reference yield:

2-methyl-7-chloroquinoline (4965-33-7) → 7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride (138786-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / acetic anhydride / xylene / 7 h / Heating

2: 98 percent / LiN₃, triethylammonium bromide / dimethylformamide / 18 h / 120 °C

With lithium azide; acetic anhydride; triethylamine hydrobromide; In N,N-dimethyl-formamide; xylene;

DOI:10.1021/jm00085a005

Reference yield:

3-Cyanobenzaldehyde (24964-64-5) → 7-chloro-2-<2-<3-(2H-tetrazol-5-yl)phenyl>ethenyl>quinoline hydrochloride (138786-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / acetic anhydride / xylene / 7 h / Heating

2: 98 percent / LiN₃, triethylammonium bromide / dimethylformamide / 18 h / 120 °C

With lithium azide; acetic anhydride; triethylamine hydrobromide; In N,N-dimethyl-formamide; xylene;

DOI:10.1021/jm00085a005

upstream raw materials:

7-chloro-2-<2-(3-cyanophenyl)ethenyl>quinoline

2-methyl-7-chloroquinoline

3-Cyanobenzaldehyde

Downstream raw materials:

2-(5-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-tetrazol-2-ylmethyl)-5-fluoro-benzoic acid

3-(5-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-tetrazol-2-ylmethyl)-thiophene-2-carboxylic acid

2-[2-(5-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-tetrazol-2-yl)-ethyl]-benzoic acid

2-(5-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-tetrazol-2-ylmethyl)-benzoic acid