(2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:857681-78-8
Molecular Formula:C₂₃H₃₇NO₆Si
Molecular Weight:451.635
Hs Code.:

Synonyms:(2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of (2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester

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Technology Process of (2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester

There total 4 articles about (2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 857681-84-6
(2R,3S)-2-Benzyloxymethyl-1-(4-methoxy-benzyl)-3-methyl-4-methylene-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester

: 857681-78-8
(2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 23 ℃; for 18h; under 760 Torr;
DOI:10.1021/ol0508734

Reference yield:

: 1027961-34-7
(2R,3S)-2-Benzyloxymethyl-3-hydroxy-4-iodomethyl-1-(4-methoxy-benzyl)-3-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

: 857681-78-8
(2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 3.53 g / triethylamine / CH₂Cl₂ / 0.5 h / 23 °C

2: 96 percent / triethylamine; DMAP / CH₂Cl₂ / 12 h / 23 °C

3: H₂ / Pd/C / ethanol / 18 h / 23 °C / 760 Torr

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/ol0508734

Reference yield:

: 704910-33-8
methyl (R)-2-(N-(4-methoxybenzyl)acrylamido)-2-((benzyloxy)methyl)-3-oxybutanoate

: 857681-78-8
(2R,3S,4R)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-3,4-dimethyl-5-oxo-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Ti(OiPr)4; cyclopentylmagnesium chloride / various solvent(s); diethyl ether / 1 h / -40 °C

1.2: I₂ / various solvent(s); tetrahydrofuran; diethyl ether / 4 h / -40 - 23 °C

2.1: 3.53 g / triethylamine / CH₂Cl₂ / 0.5 h / 23 °C

3.1: 96 percent / triethylamine; DMAP / CH₂Cl₂ / 12 h / 23 °C

4.1: H₂ / Pd/C / ethanol / 18 h / 23 °C / 760 Torr

With titanium(IV) isopropylate; dmap; hydrogen; cyclopentylmagnesium chloride; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ol0508734