bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite

Base Information

• Chemical Name: bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite
• CAS No.: 885007-77-2
• Molecular Formula: C₆₈H₆₉N₆O₁₃P
• Molecular Weight: 1209.3

Synonyms:bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite

Chemical Property of bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite

There total 4 articles about bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(Z)-1-[3-(dimethoxytrityloxy)-2-[{N-methyl-N-(2-pyridyl)-2-aminoethoxy}(diisopropylamino)phosphinoxymethyl]prop-1-enyl]thymine (885007-88-5) + (E)-1-[2-(dimethoxytrityloxymethyl)-3-hydroxyprop-1-enyl]thymine (549533-89-3) → bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite (885007-77-2)

Guidance literature:

With 1H-tetrazole; In acetonitrile; at 20 ℃; for 2.5h;

DOI:10.1039/b517504f

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite (885007-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 35 percent / pyridine / 2 h / 20 °C

2: 60 percent / tetrazole / acetonitrile / 2 h / 20 °C

3: 76 percent / tetrazole / acetonitrile / 2.5 h / 20 °C

With pyridine; 1H-tetrazole; In acetonitrile;

DOI:10.1039/b517504f

Reference yield:

1-[3'-hydroxy-2'-(hydroxymethyl)prop-1'-enyl]thymine (368890-09-9) → bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite (885007-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 35 percent / pyridine / 2 h / 20 °C

2: 60 percent / tetrazole / acetonitrile / 2 h / 20 °C

3: 76 percent / tetrazole / acetonitrile / 2.5 h / 20 °C

With pyridine; 1H-tetrazole; In acetonitrile;

DOI:10.1039/b517504f

upstream raw materials:

(Z)-1-[3-(dimethoxytrityloxy)-2-[{N-methyl-N-(2-pyridyl)-2-aminoethoxy}(diisopropylamino)phosphinoxymethyl]prop-1-enyl]thymine

(E)-1-[2-(dimethoxytrityloxymethyl)-3-hydroxyprop-1-enyl]thymine

4,4'-dimethoxytrityl chloride

1-[3'-hydroxy-2'-(hydroxymethyl)prop-1'-enyl]thymine

Downstream raw materials:

bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 885007-77-2 bis-[(E)-2-(dimethoxytrityloxymethyl)-3-(1-thyminyl)prop-2-enyl]-N-methyl-N-(2-pyridyl)-2-aminoethyl phosphite

Send

Send

Metric Ton KG G Pound L ML

Send

Send