5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide

Base Information

• Chemical Name: 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide
• CAS No.: 1092796-49-0
• Molecular Formula: C₂₂H₂₄N₂O₅
• Molecular Weight: 396.443

Synonyms:5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide

Chemical Property of 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide

Chemical Property:

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Technology Process of 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide

There total 1 articles about 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid (380607-13-6) + 3-amino-1-(4-methoxyphenyl)propan-1-one trifluoromethanesulfonate → 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide (1092796-49-0)

Guidance literature:

5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

3-amino-1-(4-methoxyphenyl)propan-1-one trifluoromethanesulfonate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jm8007823

Reference yield: 43.0%

5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide (1092796-49-0) → 7,8-dimethoxy-5-(4-methoxyphenyl)-10-methyl-3,10-dihydro-2H-azepino[3,4-b]indol-1-one (1092796-30-9)

Guidance literature:

With trifluoroacetic acid; In acetonitrile; at 80 ℃; for 18h;

DOI:10.1021/jm8007823

upstream raw materials:

5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid

Downstream raw materials:

7,8-dimethoxy-5-(4-methoxyphenyl)-10-methyl-3,10-dihydro-2H-azepino[3,4-b]indol-1-one

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