1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone

Base Information

Chemical Name:1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone
CAS No.:717110-15-1
Molecular Formula:C₁₄H₁₆ClN₃O
Molecular Weight:277.754
Hs Code.:

Synonyms:1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone

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Chemical Property of 1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone

Chemical Property:

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Technology Process of 1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone

There total 2 articles about 1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 717110-11-7
(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carbonyl chloride

: 717110-15-1
1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone

Guidance literature:: With triethylamine; In diethyl ether; at 0 ℃; for 3h;
DOI:10.1021/jm0303296

Reference yield:

: (+)-4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylic acid hydrochloride

: 717110-15-1
1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h / 20 °C

2: Et₃N / diethyl ether / 3 h / 0 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In diethyl ether; dichloromethane;
DOI:10.1021/jm0303296

Reference yield:

: 717110-15-1
1-[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-2-diazo-ethanone

: 717111-93-8
[(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-piperidin-3-yl]-acetyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 160 mg / PhCOOAg; Et₃N / 3 h / Heating

2: aq. HCl / 12 h / Heating

3: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h / 20 °C

With hydrogenchloride; oxalyl dichloride; silver benzoate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; 1: Wolff rearrangement;
DOI:10.1021/jm0303296