methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate

Base Information

• Chemical Name: methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate
• CAS No.: 1192308-13-6
• Molecular Formula: C₁₄H₁₄ClN₃O₃S
• Molecular Weight: 339.802

Synonyms:methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate

Chemical Property of methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate

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Technology Process of methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate

There total 1 articles about methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 6-benzylamino-4-chloro-2-methylthiopyrimidine-5-carboxylate (883868-65-3) → methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate (1192308-13-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 5h;

DOI:10.3987/COM-09-11715

Reference yield: 92.0%

piperidine (110-89-4) + methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate (1192308-13-6) → methyl 6-benzylamino-4-chloro-2-piperidinopyrimidine-5-carboxylate (883869-84-9) + methyl 6-benzylamino-2-methylsulfinyl-4-piperidinopyrimidine-5-carboxylate (1236950-92-7)

Guidance literature:

With triethylamine; In toluene; at 0 ℃; for 5h; chemoselective reaction;

DOI:10.3987/COM-09-11715

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + methyl 6-benzylamino-4-chloro-2-methylsulfinylpyrimidine-5-carboxylate (1192308-13-6) → methyl 6-benzylamino-4-chloro-2-morpholinopyrimidine-5-carboxylate (883869-86-1) + methyl 6-benzylamino-2-methylsulfinyl-4-morpholinopyrimidine-5-carboxylate (1192308-14-7)

Guidance literature:

With triethylamine; In toluene; at 0 ℃; for 5h; chemoselective reaction;

DOI:10.3987/COM-09-11715

upstream raw materials:

methyl 6-benzylamino-4-chloro-2-methylthiopyrimidine-5-carboxylate

Downstream raw materials:

methyl 6-benzylamino-4-chloro-2-piperidinopyrimidine-5-carboxylate

methyl 6-benzylamino-2-methylsulfinyl-4-piperidinopyrimidine-5-carboxylate

methyl 6-benzylamino-4-chloro-2-morpholinopyrimidine-5-carboxylate

methyl 6-benzylamino-2-methylsulfinyl-4-morpholinopyrimidine-5-carboxylate

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