Technology Process of 4-(octahydroindolizin-7-yl)aniline
There total 3 articles about 4-(octahydroindolizin-7-yl)aniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4-aminophenyl)boronic acid hydrochloride; 1,2,3,5,8,8a-hexahydroindolizin-7-yl trifluoromethanesulfonate;
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate;
In
1,4-dioxane; water;
at 90 ℃;
for 18h;
Inert atmosphere;
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 16h;
under 2068.65 Torr;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; zinc / water / 4 h / Reflux
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 22 h / -78 - 20 °C / Inert atmosphere
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 18 h / 90 °C / Inert atmosphere
3.2: 16 h / 20 °C / 2068.65 Torr
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; lithium hexamethyldisilazane; zinc;
In
tetrahydrofuran; 1,4-dioxane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 22 h / -78 - 20 °C / Inert atmosphere
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 18 h / 90 °C / Inert atmosphere
2.2: 16 h / 20 °C / 2068.65 Torr
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; water;
