(S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate

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Chemical Name:(S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate
CAS No.:1415829-70-7
Molecular Formula:C₂₄H₂₅F₃N₆O₄
Molecular Weight:518.496
Hs Code.:

Synonyms:(S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate

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Chemical Property of (S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate

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Technology Process of (S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate

There total 7 articles about (S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1415829-68-3
(S)-tert-butyl 2-(4-(1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate

: 69034-12-4
2-chloro-5-(trifluoromethyl)pyrimidine

: 1415829-70-7
(S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 20h;

Reference yield:

: 1131220-37-5
(S)-tert-butyl 2-(4-bromophenyl)morpholine-4-carboxylate

: 1415829-70-7
(S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 90 °C / Inert atmosphere

2: ammonium formate / 5%-palladium/activated carbon / methanol / 2 h / 60 °C

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0 - 20 °C

4: potassium carbonate / dimethyl sulfoxide / 20 h / 120 °C

With ammonium formate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5%-palladium/activated carbon; In methanol; dimethyl sulfoxide; toluene;

Reference yield:

: 920798-90-9
(S)-2-(4-bromo-phenyl)-morpholine

: 1415829-70-7
(S)-tert-butyl 2-(4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 17 h / 20 °C

2: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 90 °C / Inert atmosphere

3: ammonium formate / 5%-palladium/activated carbon / methanol / 2 h / 60 °C

4: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0 - 20 °C

5: potassium carbonate / dimethyl sulfoxide / 20 h / 120 °C

With ammonium formate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene;