2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid

Base Information

Chemical Name:2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid
CAS No.:888325-46-0
Molecular Formula:C₃₁H₃₄O₉
Molecular Weight:550.606
Hs Code.:

Synonyms:2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid

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Chemical Property of 2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid

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Technology Process of 2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid

There total 2 articles about 2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 888325-45-9
2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid dimethyl ester

: 888325-46-0
2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.583333h; sonication;
DOI:10.1016/j.bmc.2006.01.024

Reference yield:

: 221545-35-3
((2R,3R,4S,5S,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

: 888325-46-0
2-(3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-malonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h

1.2: 65 percent / tetrahydrofuran / 15 h / Heating

2.1: 95 percent / NaOH / tetrahydrofuran; H₂O / 0.58 h / 20 °C / sonication

With sodium hydroxide; sodium hydride; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2006.01.024