5-BUTYL-5-ETHYL-N,N,N',N'-TETRACYCLOHEXYL-3,7-DIOXAAZELAIC DIAMIDE

Base Information

• Chemical Name: 5-BUTYL-5-ETHYL-N,N,N',N'-TETRACYCLOHEXYL-3,7-DIOXAAZELAIC DIAMIDE
• CAS No.: 108083-23-4
• Molecular Formula: C₃₇H₆₆N₂O₄
• Molecular Weight: 602.942
• Mol file: 108083-23-4.mol

Synonyms:ETH 2137

Chemical Property of 5-BUTYL-5-ETHYL-N,N,N',N'-TETRACYCLOHEXYL-3,7-DIOXAAZELAIC DIAMIDE

Chemical Property:

• Flash Point: -4 °C
• PSA: 59.08000
• LogP: 8.59420
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Lithium ionophore IV Selectophore?, function tested ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,N,Xn
• Statements: 11-67-65-50/53-38-22
• Safety Statements: 16-62-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BUTYL-5-ETHYL-N,N,N',N'-TETRACYCLOHEXYL-3,7-DIOXAAZELAIC DIAMIDE

There total 4 articles about 5-BUTYL-5-ETHYL-N,N,N',N'-TETRACYCLOHEXYL-3,7-DIOXAAZELAIC DIAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

N-cyclohexyl-cyclohexanamine (101-83-7) + 5-butyl-5-ethyl-3,7-dioxaazelaoyl dichloride (108444-75-3) → 5-butyl-N,N,N',N'-tetracyclohexyl-5-ethyl-3,7-dioxaazelaamide (108083-23-4)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

2-butyl-2-ethylpropane-1,3-diol (115-84-4) → 5-butyl-N,N,N',N'-tetracyclohexyl-5-ethyl-3,7-dioxaazelaamide (108083-23-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 58.6 percent / BF₃*Et₂O / CH₂Cl₂ / 1.) r.t., 1 h, 2.) 45 deg C, 1.5 h

2: 95 percent / KOH / methanol; H₂O / 19 h / 80 °C

3: 71.6 percent / SOCl₂, 3 drops DMF / toluene / 1 h / 100 - 120 °C

4: 1.4 percent / Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

With potassium hydroxide; thionyl chloride; boron trifluoride diethyl etherate; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; water; toluene;

DOI:10.1002/hlca.19860690806

Reference yield:

5-butyl-5-ethyl-3,7-dioxaazelaic acid (65115-10-8) → 5-butyl-N,N,N',N'-tetracyclohexyl-5-ethyl-3,7-dioxaazelaamide (108083-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 71.6 percent / SOCl₂, 3 drops DMF / toluene / 1 h / 100 - 120 °C

2: 1.4 percent / Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; toluene;

DOI:10.1002/hlca.19860690806

upstream raw materials:

N-cyclohexyl-cyclohexanamine

5-butyl-5-ethyl-3,7-dioxaazelaoyl dichloride

2-butyl-2-ethylpropane-1,3-diol

5-butyl-5-ethyl-3,7-dioxaazelaic acid

Refernces

• 1、 Metzger, Erich,Aeschimann, Roland,Egli, Martin,Suter, Gaby,Dohner, Rene,et al.. "3,7-Dioxaazelaamides as Ionophores for Lithium Ion Selective Liquid Membrane Electrodes". . p. 1821 - 1828. Retrieved 2007/10/02.